myrTissues are macroscale human tissues to be used in drug discovery and development.
myriamed offers engineered macroscale tissues for advanced screens and target validation. myrTissues are shipped at ambient temperature for immediate use after 24h recovery in appropriate culture medium at 37° C. Each released batch of myrTissue comes with a Certificate of Analysis. Please contact us for details.
Human Engineered Heart Muscle (EHM)
myrTissue Cardio is engineered myocardium constructed from human iPSC derived cardiomyocytes and fibroblasts.
The major difference between myrTissue Cardio and other approaches is the morphological maturity of myrTissue.
The tissues show important structural and functional properties of postnatal myocardium, including: specifically aligned sarcomeres, increasingly physiologically relevant resting membrane potentials and synchronized, rhythmic contractions. This functional and structural integrity is maintained for weeks.
For more information see also Tiburcy et al. “Defined engineered human myocardium with advanced maturation for applications in heart failure modeling and repair.” Circulation vol. 135,19 (2017): 1832-1847. doi:10.1161/CIRCULATIONAHA.116.024145
human Engineered Skeletal Muscle
myrTissue-Skeletal is engineered skeletal muscle of hypaxial origin constructed from human iPSC derived myoblasts.
Tissue engineered muscle exhibits organotypic maturation and function, advanced by thyroid hormone. Regenerative competence can be shown in a cardiotoxin injury model with evidence of satellite cell activation as underlying mechanism. myrTissue-Skeletal is a hypaxial muscle model with canonical properties of bona fide skeletal muscle in vivo to study muscle development, maturation, disease, and repair.
For more information see also Shahriyari et al. “Human engineered skeletal muscle of hypaxial origin from pluripotent stem cells with advanced function and regenerative capacity.” bioRxiv preprint. doi: https://doi.org/10.1101/2021.07.12.452030
Human Engineered fibrotic tissue
myrTissue-Fibrosis is engineered fibrotic tissue constructed from human iPSC derived stromal cells.
human Bio-engineered Neuronal Organoid (BENO)
myriamed BENOs are highly interconnected neuronal networks in a macroscale tissue format.
They comprise interconnected excitatory and inhibitory neurons with supportive astrocytes and oligodendrocytes.
Giant depolarizing potential (GDP)-like events observed in early BENO cultures mimic early network activity of the fetal brain. A GABA polarity switch and reduced GDPs in >40-day BENO indicate progressive neuronal network maturation. BENOs demonstrate expedited complex network burst development after two months and evidence for long-term potentiation.)
For more information see also Zafeiriou et al. “Developmental GABA polarity switch and neuronal plasticity in Bioengineered Neuronal Organoids.” Nature communications vol. 11,1 3791. 29 Jul. 2020, doi:10.1038/s41467-020-17521-w
myrTissue are shipped at ambient temperature for immediate use after 24 h recovery in appropriate culture medium at 37°C. Each released batch of myrTissue comes with a Certificate of Analysis. Please contact us for details.