How It Works

Instead of imaging cells directly, the myrImager tracks the movement of flexible microstructured poles on which cardiac tissues are cultured under tension.

The contractile activity of the tissue induces rhythmic pole deflections, which are captured with micrometer precision and translated into quantitative functional data.

Thanks to telecentric optics, the system ensures distortion-free imaging across the entire field of view, enabling highly accurate measurement of motion amplitudes and timing independent of position within the well.

Key Advantages

• Non-invasive measurement – no direct cell imaging required
• High-throughput capability – analyze up to 48 tissues simultaneousl
• Micrometer-level resolution for detecting subtle functional change
• Distortion-free imaging using telecentric optics
• Longitudinal monitoring over days and weeks
• Fully automated data acquisition and analysis

Comprehensive Functional Analysis

The integrated software automatically detects and analyzes each contraction, extracting key parameters such as:

• Contraction and relaxation velocity (dP/dt)
• Contraction amplitude (µm)
• Beating frequency
• Variability of contraction intervals
• Contraction and relaxation duration

These metrics enable detailed insights into:

• Chronotropy – heart rate regulation
• Inotropy – contractile strength
• Lusitropy – relaxation dynamics
• Pro-arrhythmic risk – detection of irregular contraction patterns

Designed for Long-Term Studies

The myrImager enables continuous, non-invasive monitoring of cardiac tissues over extended periods. This makes it ideal for studying:

• Chronic drug effects
• Toxicity and safety profiles
• Disease progression
• Functional adaptation over time

Applications

Drug Discovery & Toxicology

• Generation of concentration–response curves (CRC)
• Determination of EC₅₀ and TOX₅₀ values
• Acute and chronic exposure studies

Gene Therapy Evaluation

• Functional assessment of CRISPR-based editing, gene overexpression, and RNA interference
• Longitudinal tracking of functional recovery and maturation

Advanced Cardiac Research

• Analysis of arrhythmia and contractility disorders
• Support for cardiac regeneration studies
• Integration into multi-modal workflows (e.g., electrophysiology, omics, metabolism)

A Platform for Multi-Parametric Insights

The myrImager can be seamlessly combined with complementary assays, enabling multi-dimensional validation of cardiac models and supporting the development of personalized therapies and next-generation treatment strategies.

Why myrImager

• Scalable and reproducible cardiac analysis
• High sensitivity without invasive imaging
• Suitable for both short-term screening and long-term studies
• Broad applicability from drug screening to gene therapy validation
• Easy to handle and suitable for use both inside and outside the incubator

The myrImager is a powerful and future-oriented solution for quantitative cardiac function analysis. By combining distortion-free imaging, automated pole tracking, and advanced data analytics, it delivers deep insights into cardiac tissue behavior across hours, days, weeks and months?

It represents a significant advancement in physiologically relevant, data-driven cardiac research, supporting applications from early drug discovery to advanced therapeutic development.