We provide a growing portfolio of patient-derived and genetically engineered disease models across cardiac, skeletal muscle and stromal applications. Disease-specific iPSC lines carrying defined mutations are available from patients, while custom mutant lines can be generated on demand using precise CRISPR genome editing in an isogenic background.

For engineered models, multiple clones are generated and selected, then rigorously characterized at the genomic, molecular and functional levels to confirm the desired mutation and its biological consequences. Following differentiation into relevant cell types, models can be evaluated as 2D myrCells or advanced 3D myrTissue models, enabling functional phenotyping and assessment of disease-associated phenotypes that recapitulate key aspects of human pathophysiology.

Disease models can also be generated in specific reporter backgrounds, tailored to the biological question and assay requirements. These reporter models enable defined, quantitative readouts suitable for high-content imaging and high-throughput screening (HTS), including longitudinal assessment of cellular and tissue phenotypes.

Explore available disease models and reporter lines in the myrCell section, or contact us to discuss a specific mutation, reporter model or custom disease model.